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Article

Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons.

Development (Cambridge, England) - 1 Jul 2007

Murchison Nicholas D, Price Brian A, Conner David A, Keene Douglas R, Olson Eric N, Tabin Clifford J, Schweitzer Ronen

Abstract excerpt

The scleraxis (Scx) gene, encoding a bHLH transcription factor, is expressed in the progenitors and cells of all tendon tissues. To determine Scx function, we produced a mutant null allele. Scx-/- mice were viable, but showed severe tendon defects, which manifested in a drastically limited use of all paws and back muscles and a complete inability to move the tail. Interestingly, although the differentiation of...

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PMID: 17567668
DOI: 10.1242/dev.001933

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