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Article

Mechano-regulated tenascin-C orchestrates muscle repair.

Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2008

Flück Martin, Mund Sonja I, Schittny Johannes C, Klossner Stephan, Durieux Anne-Cécile, Giraud Marie-Noëlle

Abstract excerpt

Tenascin-C (TNC) is a mechano-regulated, morphogenic, extracellular matrix protein that is associated with tissue remodeling. The physiological role of TNC remains unclear because transgenic mice engineered for a TNC deficiency, via a defect in TNC secretion, show no major pathologies. We hypothesized that TNC-deficient mice would demonstrate defects in the repair of damaged leg muscles, which would be of...

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Source

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Identifiers

PMID: 18757758
DOI: 10.1073/pnas.0805365105
PMCID: PMC2533246

Genes

TNC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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