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Article

Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype.

eLife - 19 Jan 2023

Korcari Antonion, Nichols Anne E C, Buckley Mark R, Loiselle Alayna E

Abstract excerpt

Aged tendons have disrupted homeostasis, increased injury risk, and impaired healing capacity. Understanding mechanisms of homeostatic disruption is crucial for developing therapeutics to retain tendon health through the lifespan. Here, we developed a novel model of accelerated tendon extracellular matrix (ECM) aging via depletion of Scleraxis-lineage cells in young mice (Scx-DTR). Scx-DTR recapitulates many...

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Identifiers

PMID: 36656751
DOI: 10.7554/eLife.84194
PMCID: PMC9908079

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