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The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance

1 Jun 2022

Abstract excerpt

How mechanical stress affects physical performance via tendons is not fully understood. Piezo1 is a mechanosensitive ion channel, and E756del PIEZO1 was recently found as a gain-of-function variant that is common in individuals of African descent. We generated tendon-specific knock-in mice using R2482H Piezo1 , a mouse gain-of-function variant, and found that they had higher jumping abilities and faster running...

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PMID: 35648809
DOI: 10.1126/scitranslmed.abj5557

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