Article
Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2008
Haining W Nicholas, Ebert Benjamin L, Subrmanian Aravind, Wherry E John, Eichbaum Quentin, Evans John W, Mak Raymond, Rivoli Stephen, Pretz Jennifer, Angelosanto Jill, Smutko John S, Walker Bruce D, Kaech Susan M, Ahmed Rafi, Nadler Lee M, Golub Todd R
Abstract excerpt
After Ag encounter, naive lymphocytes differentiate into populations of memory cells that share a common set of functions including faster response to Ag re-exposure and the ability to self-renew. However, memory lymphocytes in different lymphocyte lineages are functionally and phenotypically diverse. It is not known whether discrete populations of T and B cells use similar transcriptional programs during...
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