Article

Distinct phenotypic consequences of cholangiocarcinoma-associated FGFR2 alterations depend on biliary epithelial cell state

2024-09-02

Abstract excerpt

Epithelial cancers disrupt tissue architecture and are often driven by mutations in genes that play important roles in normal epithelial morphogenesis. The intrahepatic biliary system is an epithelial tubular network that forms within the developing liver via the de novo initiation and expansion of apical lumens. Intrahepatic biliary tumors (intrahepatic cholangiocarcinoma) commonly harbor activating genomic alter...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9369b26e-e054-5db6-8b72-48bcda34fc56
DOI: 10.1101/2024.08.30.610360

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct phenotypic consequences of cholangiocarcinoma-associated FGFR2 alterations depend on biliary epithelial cell stateDOI 10.1101/2024.08.30.610360Read

Functions of FGFR2 corrupted by translocations in intrahepatic cholangiocarcinoma.Semantic proximity Read

Development of the Intrahepatic and Extrahepatic Biliary Tract: A Framework for Understanding Congenital DiseasesSemantic proximity Read

Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomasSemantic proximity Read

FGFR2 fusion protein-driven mouse models of intrahepatic cholangiocarcinoma unveil a necessary role for Erk signalingSemantic proximity Read

Polycystic liver diseases: congenital disorders of cholangiocyte signaling.Semantic proximity Read

FGFR2 Inhibition in Cholangiocarcinoma.Semantic proximity Read

Genetics of Biliary Tract Cancers and Emerging Targeted TherapiesSemantic proximity Read

FGFR2 Extracellular Domain In-Frame Deletions Are Therapeutically Targetable Genomic Alterations That Function as Oncogenic Drivers in CholangiocarcinomaSemantic proximity Read

A human multi-lineage hepatic organoid model for liver fibrosis.Semantic proximity Read

Human branching cholangiocyte organoids recapitulate functional bile duct formationSemantic proximity Read

Cholangiocytic differentiation drives cell proliferation in hepatoblastoma through Wnt-dependent FGF19 signalingSemantic proximity Read

Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoidsSemantic proximity Read