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Article

Two-Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence.

Angewandte Chemie (International ed. in English) - 3 May 2021

Gao Ying, Hu Yulu, Liu Qimeng, Li Xiaokang, Li Xinming, Kim Chu-Young, James Tony D, Li Jian, Chen Xi, Guo Yuan

Abstract excerpt

The tracking of cellular senescence usually depends on the detection of senescence-associated β-galactosidase (SA-β-gal). Previous probes for SA-β-gal with this purpose only cover a single dimension: the accumulation of this enzyme in lysosomes. However, this is insufficient to determine the destiny of senescence because endogenous β-gal enriched in lysosomes is not only related to senescence, but also to some...

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PMID: 33624914
DOI: 10.1002/anie.202101278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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