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Article

Preliminary ocular histopathological observations on heterozygous NEMO-deficient mice.

Experimental eye research - 1 Mar 2009

Oster Stephen F, McLeod D Scott, Otsuji T, Goldberg Morton F, Lutty Gerard A

Abstract excerpt

The majority of patients with incontinentia pigmenti (IP) have a mutation in the nuclear factor-kappa-beta essential modulator (NEMO) gene, and mice with a targeted deletion of NEMO exhibit skin pathology remarkably similar to the human disease. This study characterizes the retinal vascular abnormalities of NEMO-deficient mice, and compares this phenotype to known features of human IP. Nineteen heterozygous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19068214
DOI: 10.1016/j.exer.2008.10.027
PMCID: PMC4943837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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