Article
Lipid profiling of mouse intestinal organoids for studying APC mutations.
Bioscience reports - 26 Mar 2021
Jukes Zoë, Freier Anne, Glymenaki Maria, Brown Richard, Parry Lee, Want Elizabeth, Vorkas Panagiotis A, Li Jia V
Abstract excerpt
Inactivating mutations including both germline and somatic mutations in the adenomatous polyposis coli (APC) gene drives most familial and sporadic colorectal cancers. Understanding the metabolic implications of this mutation will aid to establish its wider impact on cellular behaviour and potentially inform clinical decisions. However, to date, alterations in lipid metabolism induced by APC mutations remain...
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