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Detection of Metabolic Alterations in Non-tumor Gastrointestinal Tissue of the <i>Apc</i><sup>Min/+</sup> Mouse by <sup>1</sup>H MAS NMR Spectroscopy

21 Jan 2009

Abstract excerpt

In this study, we have used metabolic profiling (metabolomics/metabonomics) via high resolution magic angle spinning (HRMAS) and solution state (1)H NMR spectroscopy to characterize small bowel and colon tissue from the Apc(Min/+) mouse model of early gastrointestinal (GI) tumorigenesis. Multivariate analysis indicated the presence of metabolic differences between the morphologically normal/non-tumor tissue from...

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PMID: 19159281
DOI: 10.1021/pr800793w

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