Article
Evidence of skewed X-chromosome inactivation in 47,XXY and 48,XXYY Klinefelter patients.
American journal of medical genetics - 1 Jan 2001
Iitsuka Y, Bock A, Nguyen D D, Samango-Sprouse C A, Simpson J L, Bischoff F Z
Abstract excerpt
Klinefelter (47,XXY) syndrome occurs in approximately 1:800 male births and accounts for about 10-20% of males attending infertility clinics. Recent studies have shown no obvious phenotypic differences between subjects in which the extra X-chromosome is of paternal or maternal origin; however, a minority of Klinefelter patients are adversely affected clinically and intellectually to an exceptional level, and the...
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