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Article

Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa.

Biochemistry - 25 May 2004

Suzuki Naomi, Itoh Shinji, Poon Kinning, Masutani Chikahide, Hanaoka Fumio, Ohmori Haruo, Yoshizawa Itsuo, Shibutani Shinya

Abstract excerpt

Newly discovered human DNA polymerase (pol) eta and kappa are highly expressed in the reproductive organs, such as testis, ovary, and uterus, where steroid hormones are produced. Because treatment with estrogen increases the risk of developing breast, ovary, and endometrial cancers, miscoding events occurring at model estrogen-derived DNA adducts were explored using pol eta and a truncated form of human pol kappa...

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Identifiers

PMID: 15147214
DOI: 10.1021/bi0360298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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