Article
Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis.
Molecular cell - 18 Feb 2021
Mukherjee Radha, Vanaja Kiran G, Boyer Jacob A, Gadal Sunyana, Solomon Hilla, Chandarlapaty Sarat, Levchenko Andre, Rosen Neal
Abstract excerpt
The PI3K pathway regulates cell metabolism, proliferation, and migration, and its dysregulation is common in cancer. We now show that both physiologic and oncogenic activation of PI3K signaling increase the expression of its negative regulator PTEN. This limits the duration of the signal and output of the pathway. Physiologic and pharmacologic inhibition of the pathway reduces PTEN and contributes to the rebound...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.