Article
4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors.
Cancer cell - 13 Jul 2010
She Qing-Bai, Halilovic Ensar, Ye Qing, Zhen Wei, Shirasawa Senji, Sasazuki Takehiko, Solit David B, Rosen Neal
Abstract excerpt
PIK3CA and PTEN alterations are common in human cancer, but only a fraction of such tumors are dependent upon AKT signaling. AKT independence is associated with redundant activation of cap-dependent translation mediated by convergent regulation of the translational repressor 4E-BP1 by the AKT and ERK pathways. This provides mechanistic bases for the limited activity of AKT and MEK inhibitors in tumors with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.