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Article

Compensation of the metabolic costs of antibiotic resistance by physiological adaptation in Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Aug 2013

Händel Nadine, Schuurmans J Merijn, Brul Stanley, ter Kuile Benno H

Abstract excerpt

Antibiotic resistance is often associated with metabolic costs. To investigate the metabolic consequences of antibiotic resistance, the genomic and transcriptomic profiles of an amoxicillin-resistant Escherichia coli strain and the wild type it was derived from were compared. A total of 125 amino acid substitutions and 7 mutations that were located <1,000 bp upstream of differentially expressed genes were found...

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Identifiers

PMID: 23716056
DOI: 10.1128/AAC.02096-12
PMCID: PMC3719774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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