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Ro60—Roles in RNA Processing, Inflammation, and Rheumatic Autoimmune Diseases

14 Jul 2024

Abstract excerpt

The Ro60/SSA2 autoantigen is an RNA-binding protein and a core component of nucleocytoplasmic ribonucleoprotein (RNP) complexes. Ro60 is essential in RNA metabolism, cell stress response pathways, and cellular homeostasis. It stabilises and mediates the quality control and cellular distribution of small RNAs, including YRNAs (for the 'y' in 'cytoplasmic'), retroelement transcripts, and misfolded RNAs. Ro60...

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PMID: 39062948
DOI: 10.3390/ijms25147705

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