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Article

Cerebrovascular damage after midlife transient hypertension in non-transgenic and Alzheimer's disease rats.

Brain research - 1 May 2021

Lai Aaron Y, Joo Illsung L, Trivedi Arunachala U, Dorr Adrienne, Hill Mary E, Stefanovic Bojana, McLaurin JoAnne

Abstract excerpt

Hypertension, including transient events, is a major risk factor for developing late-onset dementia and Alzheimer's disease (AD). Anti-hypertensive drugs facilitate restoration of normotension without amelioration of increased dementia risk suggesting that transient hypertensive insults cause irreversible damage. This study characterized the contribution of transient hypertension to sustained brain damage as a...

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Identifiers

PMID: 33582120
DOI: 10.1016/j.brainres.2021.147369
PMCID: PMC8005286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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