Article
Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats.
Science translational medicine - 4 Jul 2018
Rajani Rikesh M, Quick Sophie, Ruigrok Silvie R, Graham Delyth, Harris Sarah E, Verhaaren Benjamin F J, Fornage Myriam, Seshadri Sudha, Atanur Santosh S, Dominiczak Anna F, Smith Colin, Wardlaw Joanna M, Williams Anna
Abstract excerpt
Dementia is a major social and economic problem for our aging population. One of the most common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic resonance scans of SVD patients typically show white matter abnormalities, but we do not understand the mechanistic pathological link between blood vessels and white matter myelin damage. Hypertension is suggested as the cause of sporadic SVD,...
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