Article
Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein.
Circulation - 24 Mar 2009
Decano Julius L, Viereck Jason C, McKee Ann C, Hamilton James A, Ruiz-Opazo Nelson, Herrera Victoria L M
Abstract excerpt
BACKGROUND: Early-life risk factor exposure increases aortic atherosclerosis and blood pressure in humans and animal models; however, limited insight has been gained as to end-organ complications. METHODS AND RESULTS: We investigated the effects of early-life Na exposure (0.23% versus 0.4% NaCl regular rat chow) on vascular disease outcomes using the inbred, transgenic [hCETP](25) Dahl salt-sensitive hypertensive...
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