Article

Therapeutic effects of bumetanide on neurological dysfunction in a mouse model of Angelman syndrome

2022-04-22

Abstract excerpt

Angelman syndrome is a neurodevelopmental disorder caused by loss of function of the maternally expressed UBE3A gene. Treatments for the main manifestations, including cognitive dysfunction or epilepsy, are still under development. Recently, the Cl - importer Na + -K + -Cl - cotransporter 1 (NKCC1) has gained attention as a therapeutic target in many neurological disorders. Dysregulation of neuronal intracellular...

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Literature Corpus work: c40fd1d4-dab4-5f51-b267-453143f285f8
DOI: 10.21203/rs.3.rs-1534850/v1

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