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Article

Treatment during a vulnerable developmental period rescues a genetic epilepsy.

Nature medicine - 1 Dec 2015

Marguet Stephan Lawrence, Le-Schulte Vu Thao Quyen, Merseburg Andrea, Neu Axel, Eichler Ronny, Jakovcevski Igor, Ivanov Anton, Hanganu-Opatz Ileana Livia, Bernard Christophe, Morellini Fabio, Isbrandt Dirk

Abstract excerpt

The nervous system is vulnerable to perturbations during specific developmental periods. Insults during such susceptible time windows can have long-term consequences, including the development of neurological diseases such as epilepsy. Here we report that a pharmacological intervention timed during a vulnerable neonatal period of cortical development prevents pathology in a genetic epilepsy model. By using mice...

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PMID: 26594844
DOI: 10.1038/nm.3987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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