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Article

MRS in presymptomatic MAPT mutation carriers: a potential biomarker for tau-mediated pathology.

Neurology - 31 Aug 2010

Kantarci K, Boeve B F, Wszolek Z K, Rademakers R, Whitwell J L, Baker M C, Senjem M L, Samikoglu A R, Knopman D S, Petersen R C, Jack C R

Abstract excerpt

OBJECTIVE: To determine the proton magnetic resonance spectroscopy ((1)H MRS) changes in carriers of microtubule-associated protein (MAPT) mutations in a case-control study. METHODS: Patients with MAPT mutations (N279K, V337M, R406W, IVS9-10G>T, P301L) from 5 different families (n = 24) underwent MRI and single voxel (1)H MRS from the posterior cingulate gyrus inferior precuneus at 3 T. Ten of the patients were...

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Identifiers

PMID: 20805522
DOI: 10.1212/WNL.0b013e3181f073c7
PMCID: PMC2938968

Genes

MAPT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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