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Article

Accelerated aging phenotypes in the retinal pigment epithelium of Zmpste24-deficient mice.

Biochemical and biophysical research communications - 3 Dec 2022

Chae Jae-Byoung, Park Chul-Woo, Lee Hyeong Min, Choi Leo Sungwong, Park Chaehee, Kim Junghoon, Shin Jaejin, Hyeon Jooseung, Lee Jihan, Lee Hyungwoo, Park Hyung Soon, Nam Chang-Hoon, Chung Hyewon

Abstract excerpt

Age-related macular degeneration (AMD) is a chronic and progressive disease characterized by degeneration of the retinal pigment epithelium (RPE) and retina that ultimately leads to loss of vision. The pathological mechanisms of AMD are not fully known. Cellular senescence, which is a state of cell cycle arrest induced by DNA-damage or aging, is hypothesized to critically affect the pathogenesis of AMD. In this...

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PMID: 36201882
DOI: 10.1016/j.bbrc.2022.09.061

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