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Article

Pgc-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice.

Disease models & mechanisms - 16 Aug 2018

Zhang Meng, Chu Yi, Mowery Joseph, Konkel Brandon, Galli Susana, Theos Alexander C, Golestaneh Nady

Abstract excerpt

Age-related macular degeneration (AMD) is the major cause of blindness in the elderly in developed countries and its prevalence is increasing with the aging population. AMD initially affects the retinal pigment epithelium (RPE) and gradually leads to secondary photoreceptor degeneration. Recent studies have associated mitochondrial damage with AMD, and we have observed mitochondrial and autophagic dysfunction and...

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Identifiers

PMID: 29925537
DOI: 10.1242/dmm.032698
PMCID: PMC6176989

Genes

RPE
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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