Article
Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation.
Nature communications - 8 Feb 2021
Kok Sau Yee, Oshima Hiroko, Takahashi Kei, Nakayama Mizuho, Murakami Kazuhiro, Ueda Hiroki R, Miyazono Kohei, Oshima Masanobu
Abstract excerpt
A concept of polyclonal metastasis has recently been proposed, wherein tumor cell clusters break off from the primary site and are disseminated. However, the involvement of driver mutations in such polyclonal mechanism is not fully understood. Here, we show that non-metastatic AP cells metastasize to the liver with metastatic AKTP cells after co-transplantation to the spleen. Furthermore, AKTP cell depletion...
Topics
- Animals
- Cell Aggregation
- Cell Proliferation
- Clone Cells
- Fibrosis
- Hepatic Stellate Cells
- Liver
- Mice, Inbred NOD
- Neoplasm Metastasis
- Neoplasms
- Organoids
- Phenotype
- Spleen
- Transforming Growth Factor beta