Article
Transient commensal clonal interactions can drive tumor metastasis.
Nature communications - 16 Nov 2020
Naffar-Abu Amara Suha, Kuiken Hendrik J, Selfors Laura M, Butler Timothy, Leung Marco L, Leung Cheuk T, Kuhn Elaine P, Kolarova Teodora, Hage Carina, Ganesh Kripa, Panayiotou Richard, Foster Rosemary, Rueda Bo R, Aktipis Athena, Spellman Paul, Ince Tan A, Xiu Joanne, Oberley Matthew, Gatalica Zoran, Navin Nicholas, Mills Gordon B, Bronson Rodrick T, Brugge Joan S
Abstract excerpt
The extent and importance of functional heterogeneity and crosstalk between tumor cells is poorly understood. Here, we describe the generation of clonal populations from a patient-derived ovarian clear cell carcinoma model which forms malignant ascites and solid peritoneal tumors upon intraperitoneal transplantation in mice. The clonal populations are engineered with secreted Gaussia luciferase to monitor tumor...
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