Article

Modifications of the 22A apoA-I mimetic peptide sequence improve the anti-atherosclerotic properties of synthetic HDL

2025-08-16

Abstract excerpt

Synthetic high-density lipoprotein (sHDL) constituted of apolipoprotein A-I (apoA-I) mimetic peptides and phospholipids are nanometer-scale particles designed to recreate biological functions of HDL particles in the context of cardiovascular disease. Particularly, the therapeutic efficacy of sHDL particles is attributed to their ability to promote reverse cholesterol transport (RCT), a process where accumulated ch...

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Literature Corpus work: 01c37fa4-d1d5-51ae-b5d9-8a02fdf645e8
DOI: 10.1101/2025.08.13.670037

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