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Article

A Systems Biology Approach for Hypothesizing the Effect of Genetic Variants on Neuroimaging Features in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Golriz Khatami Sepehr, Domingo-Fernández Daniel, Mubeen Sarah, Hoyt Charles Tapley, Robinson Christine, Karki Reagon, Iyappan Anandhi, Kodamullil Alpha Tom, Hofmann-Apitius Martin

Abstract excerpt

BACKGROUND: Neuroimaging markers provide quantitative insight into brain structure and function in neurodegenerative diseases, such as Alzheimer's disease, where we lack mechanistic insights to explain pathophysiology. These mechanisms are often mediated by genes and genetic variations and are often studied through the lens of genome-wide association studies. Linking these two disparate layers (i.e., imaging and...

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Source

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Identifiers

PMID: 33554913
DOI: 10.3233/JAD-201397
PMCID: PMC8075382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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