Article
Mixed Sputum Granulocyte Longitudinal Impact on Lung Function in the Severe Asthma Research Program.
American journal of respiratory and critical care medicine - 1 Apr 2021
Hastie Annette T, Mauger David T, Denlinger Loren C, Coverstone Andrea, Castro Mario, Erzurum Serpil, Jarjour Nizar, Levy Bruce D, Meyers Deborah A, Moore Wendy C, Phillips Brenda R, Wenzel Sally E, Fahy John V, Israel Elliot, Bleecker Eugene R
Abstract excerpt
Rationale: Some reports indicate longitudinal variability in sputum differential cell counts, whereas others describe stability. Highly variable sputum eosinophil percentages are associated with greater lung function loss than persistently elevated eosinophil percentages, but elevated neutrophils are linked to more severe asthma.Objectives: To examine sputum granulocyte stability or variability longitudinally and...
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