Article
Clinical phenotyping of asthma patients with elevated sputum eosinophils and low blood eosinophils: a post-hoc analysis of the multicentre ATLANTIS cohort.
EBioMedicine - 1 Aug 2026
Kuks Pauline J M, Aabed Atheer M A, Premereur Lauren C A, Kraft Monica, Siddiqui Salman, Fabbri Leonardo M, Beghé Bianca, Rabe Klaus F, Papi Alberto, Brightling Christopher E, Singh Dave, Piraino Alessio, Scaffidi-Argentina Ulrica, Kocks Janwillem H, Lahousse Lies, Kerstjens Huib A M, Heijink Irene H, Pouwels Simon D, Slebos Dirk-Jan, van den Berge Maarten
Abstract excerpt
BACKGROUND: Patients with eosinophilic asthma are responsive to treatment with corticosteroids and biologics. Eosinophilia is usually identified based on blood eosinophil counts, but there is discordance between blood and sputum in some cases. A subset of patients may have sputum eosinophilia despite low blood eosinophil levels. The clinical implications of this so-called isolated sputum eosinophilia are unknown....
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