Article
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic.
American journal of respiratory and critical care medicine - 15 Mar 2012
McGrath Kelly Wong, Icitovic Nikolina, Boushey Homer A, Lazarus Stephen C, Sutherland E Rand, Chinchilli Vernon M, Fahy John V
Abstract excerpt
RATIONALE: Airway eosinophilia is typical of asthma, and many controller treatments target eosinophilic disease. Asthma is clinically heterogeneous, however, and a subgroup of people with asthma do not have airway eosinophilia. The size of this subgroup is uncertain because prior studies have not examined repeated measures of sputum cytology to determine when people with asthma have intermittent versus persistent...
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