Article
Impact of CD34 + Bone Marrow Cell Heterogeneity and HMOX1 Promoter Polymorphism on Neutrophil Engraftment in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation.
European journal of haematology - 1 Sept 2026
Bukowska-Strakova Karolina, Moskwa Monika, Sieminska Izabela, Zatorska-Kwiecień Magdalena, Sawa Monika, Wieczorek Aleksandra, Pocheć Anna, Gozdzik Jolanta, Siedlar Maciej, Pawinska-Wasikowska Katarzyna
Abstract excerpt
Hematopoietic stem cell transplantation (HSCT) is a therapeutic option for various pediatric diseases. In this study, we analyzed 52 pediatric patients undergoing allogeneic HSCT to determine how the content of myeloid and lymphoid CD34+ progenitor cells, as well as HMOX1 promoter polymorphisms, affects neutrophil (NE) and platelet engraftment (PE). We found that NE was significantly accelerated in patients who...
Topics
- Humans
- Heme Oxygenase-1
- Hematopoietic Stem Cell Transplantation
- Neutrophils
- Antigens, CD34
- Promoter Regions, Genetic
- Child
- Female
- Polymorphism, Genetic