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Article

Prediction of Graft-Versus-Host Disease in Humans by Donor Gene-Expression Profiling

26 Jan 2007

Abstract excerpt

BACKGROUND: Graft-versus-host disease (GVHD) results from recognition of host antigens by donor T cells following allogeneic hematopoietic cell transplantation (AHCT). Notably, histoincompatibility between donor and recipient is necessary but not sufficient to elicit GVHD. Therefore, we tested the hypothesis that some donors may be "stronger alloresponders" than others, and consequently more likely to elicit...

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PMID: 17378698
DOI: 10.1371/journal.pmed.0040023

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