Article
Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.
American journal of respiratory and critical care medicine - 1 Apr 2021
Hallmark Brian, Wegienka Ganesa, Havstad Suzanne, Billheimer Dean, Ownby Dennis, Mendonca Eneida A, Gress Lisa, Stern Debra A, Myers Jocelyn Biagini, Khurana Hershey Gurjit K, Hoepner Lori, Miller Rachel L, Lemanske Robert F, Jackson Daniel J, Gold Diane R, O'Connor George T, Nicolae Dan L, Gern James E, Ober Carole, Wright Anne L, Martinez Fernando D
Abstract excerpt
Rationale: Birth cohort studies have identified several temporal patterns of wheezing, only some of which are associated with asthma. Whether 17q12-21 genetic variants, which are closely associated with asthma, are also associated with childhood wheezing phenotypes remains poorly explored.Objectives: To determine whether wheezing phenotypes, defined by latent class analysis (LCA), are associated with nine...
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