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Article

Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates.

American journal of respiratory and critical care medicine - 15 Apr 2022

Haider Sadia, Granell Raquel, Curtin John, Fontanella Sara, Cucco Alex, Turner Stephen, Simpson Angela, Roberts Graham, Murray Clare S, Holloway John W, Devereux Graham, Cullinan Paul, Arshad Syed Hasan, Custovic Adnan

Abstract excerpt

Rationale: Longitudinal modeling of current wheezing identified similar phenotypes, but their characteristics often differ between studies. Objectives: We propose that a more comprehensive description of wheeze may better describe trajectories than binary information on the presence/absence of wheezing. Methods: We derived six multidimensional variables of wheezing spells from birth to adolescence (including...

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Identifiers

PMID: 35050846
DOI: 10.1164/rccm.202108-1821OC
PMCID: PMC9838626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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