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Article

Mitochondrial haplogroup G is associated with nonalcoholic fatty liver disease, while haplogroup A mitigates the effects of PNPLA3.

Endocrinology, diabetes & metabolism - 1 Jan 2021

Gusdon Aaron M, Hui You, Chen Jing, Mathews Clayton E, Qu Shen

Abstract excerpt

Objectives: Mitochondrial dysfunction plays a pivotal role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). We hypothesized that mitochondrial DNA (mtDNA) haplogroups affect the risk of NAFLD in Han Chinese patients and interact with PNPLA3 genotypes. Design: NAFLD and control patients were recruited from a tertiary care centre. The mitochondrial genome was amplified in overlapping segments and...

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Identifiers

PMID: 33532620
DOI: 10.1002/edm2.187
PMCID: PMC7831202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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