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Article

Mitochondrial genome architecture in non-alcoholic fatty liver disease.

The Journal of pathology - 1 Dec 2016

Sookoian Silvia, Flichman Diego, Scian Romina, Rohr Cristian, Dopazo Hernán, Gianotti Tomas Fernández, Martino Julio San, Castaño Gustavo O, Pirola Carlos J

Abstract excerpt

Non-alcoholic fatty liver disease (NAFLD) is associated with mitochondrial dysfunction, a decreased liver mitochondrial DNA (mtDNA) content, and impaired energy metabolism. To understand the clinical implications of mtDNA diversity in the biology of NAFLD, we applied deep-coverage whole sequencing of the liver mitochondrial genomes. We used a multistage study design, including a discovery phase, a...

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Share to Genome, Mitochondrial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Cirrhosis

Share to Mitochondria, Liver

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Share to Non-alcoholic Fatty Liver Disease

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Source

Identifiers

PMID: 27577682
DOI: 10.1002/path.4803

Genes

POLG
POLG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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