Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT.

Mutation research - 1 Jan 2026

Hong Lingju, Ke Shaoying, Lin Shaoze, Wu Gongle, Wang Congren

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (LIHC) is the most common primary liver cancer, with high recurrence and metastasis rates, and its molecular mechanisms remain incompletely understood. METHODS: The cancer genome atlas (TCGA) database was used to obtain LIHC-related information. TNMplot, gene expression profiling interactive analysis (GEPIA), and kaplan-meier plotter were used for differential gene expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Carcinoma, Hepatocellular
Share to E2F1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Liver Neoplasms

Share to NIMA-Related Kinases

Share to Receptors, Notch

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 41965966
DOI: 10.1016/j.mrfmmm.2026.111935

Genes

NEK2
E2F1
CTNNB1
HES1
HEY1
JAG1
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT.PMID 41965966Read ↗

NIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferationSemantic proximity Read ↗

PDLIM2 prevents the malignant phenotype of hepatocellular carcinoma cells by negatively regulating β-catenin.Semantic proximity Read ↗

Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database.Semantic proximity Read ↗

ALKBH5 promotes Liver hepatocellular carcinoma cell proliferation, migration and invasion by regulating TTI1 expressionSemantic proximity Read ↗

NEK2 Promotes the Migration, Invasion, Proliferation and Drug Resistance of ESCC Through the E2F1-IGF2 PathwaySemantic proximity Read ↗

Decreased expression of KPNA2 in Hepatocellular carcinoma infers favorable prognosis and high immune infiltrating levelSemantic proximity Read ↗

Identification and validation of functional roles for three MYC-associated genes in hepatocellular carcinomaSemantic proximity Read ↗

Exploring the Prognostic Value and Biological Function of CPNE1 Gene in Hepatocellular CarcinomaSemantic proximity Read ↗

Oncogenic role of the Notch pathway in primary liver cancerSemantic proximity Read ↗

MELK is an oncogenic kinase essential for early hepatocellular carcinoma recurrence.Semantic proximity Read ↗

NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF / MEK / ERK / TWIST signaling pathwaySemantic proximity Read ↗

Identification of the LNC02362–EFNA5 axis as a Potential Prognosis Biomarker in Hepatocellular Carcinoma via Comprehensive Bioinformatics AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.