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PARP1 rs1136410 C/C genotype associated with an increased risk of esophageal cancer in smokers.

Molecular biology reports - 1 Feb 2021

Zhou Rongmiao, Li Yan, Wang Na, Niu Chaoxu, Huang Xi, Cao Shiru, Huo Xiangran

Abstract excerpt

DNA repair system plays a crucial role in maintaining genomic integrity and stability and in protecting against cancer. Poly(ADP-ribose) polymerase 1 (PARP1) functions as a key enzyme in the base excision repair (BER) pathway. Single nucleotide polymorphism (SNP) that could affect the function or expression of PARP1 gene might be associated with the risk of cancer. This study was designed to evaluate the...

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DNA Repair
Esophageal Neoplasms
Genetic Association Studies
Genetic Predisposition to Disease
Poly (ADP-Ribose) Polymerase-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 33528729
DOI: 10.1007/s11033-021-06169-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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