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Article

Contributions of PARP-1 rs1136410 C>T polymorphism to the development of cancer.

Journal of cellular and molecular medicine - 1 Dec 2020

Li Hunian, Zha Yongjiu, Du Fang, Liu Jie, Li Xiaoquan, Zhao Xu

Abstract excerpt

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear chromatin-associated enzyme involved in the DNA damage response. SNP rs1136410 C>T, the most studied polymorphism in PARP-1 gene, is highly implicated in the susceptibility of cancer. However, the roles of PARP-1 rs1136410 C>T on cancer risk vary from different studies. We comprehensively screened all qualified publications from several databases, including...

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Identifiers

PMID: 33108038
DOI: 10.1111/jcmm.16027
PMCID: PMC7753995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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