PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies.

doi:10.1371/journal.pone.0098022

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Article

PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies.

PloS one - 1 Jan 2014

Qin Qin, Lu Jing, Zhu Hongcheng, Xu Liping, Cheng Hongyan, Zhan Liangliang, Yang Xi, Zhang Chi, Sun Xinchen

Abstract excerpt

BACKGROUND: Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear chromatin-associated enzyme involved in several important cellular processes, particularly in the DNA repair system. PARP-1 rs1136410: C>T is among the most studied polymorphisms and likely involved in human carcinogenesis. However, results from previous studies are inconclusive. Thus, a meta-analysis was conducted to derive a more precise estimation...

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PMID: 24853559
DOI: 10.1371/journal.pone.0098022
PMCID: PMC4031170

Genes

XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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