Telomere shortening in human diseases

doi:10.1111/febs.12326

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Telomere shortening in human diseases

6 May 2013

Abstract excerpt

The discovery of telomeres dates back to the early 20th century. In humans, telomeres are heterochromatic structures with tandem DNA repeats of 5'-TTAGGG-3' at the chromosomal ends. Telomere length varies greatly among species and ranges from 10 to 15 kb in humans. With each cell division, telomeres shorten progressively because of the 'end-replication problem'. Short or dysfunctional telomeres are often...

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PMID: 23647631
DOI: 10.1111/febs.12326

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