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Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis

11 Jun 2010

Abstract excerpt

We performed single-molecule telomere length and telomere fusion analysis in patients at different stages of chronic lymphocytic leukemia (CLL). Our work identified the shortest telomeres ever recorded in primary human tissue, reinforcing the concept that there is significant cell division in CLL. Furthermore, we provide direct evidence that critical telomere shortening, dysfunction, and fusion contribute to...

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PMID: 20538793
DOI: 10.1182/blood-2010-02-272104

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