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In vivo interactome profiling by enzyme‐catalyzed proximity labeling

29 Jan 2021

Abstract excerpt

Enzyme-catalyzed proximity labeling (PL) combined with mass spectrometry (MS) has emerged as a revolutionary approach to reveal the protein-protein interaction networks, dissect complex biological processes, and characterize the subcellular proteome in a more physiological setting than before. The enzymatic tags are being upgraded to improve temporal and spatial resolution and obtain faster catalytic dynamics and...

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PMID: 33514425
DOI: 10.1186/s13578-021-00542-3

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