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Article

Functional role of vanilloid transient receptor potential 4-canonical transient receptor potential 1 complex in flow-induced Ca2+ influx.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2010

Ma Xin, Qiu Shuang, Luo Jianhong, Ma Yan, Ngai Ching-Yuen, Shen Bing, Wong Ching-on, Huang Yu, Yao Xiaoqiang

Abstract excerpt

OBJECTIVE: The present study is aimed at investigating the interaction of TRPV4 with TRPC1 and the functional role of such an interaction in flow-induced Ca(2+) influx. Hemodynamic blood flow is an important physiological factor that modulates vascular tone. One critical early event in this process is a cytosolic Ca(2+) ([Ca(2+)](i)) rise in endothelial cells in response to flow. METHODS AND RESULTS: With the use...

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Source

Identifiers

PMID: 20093626
DOI: 10.1161/ATVBAHA.109.196584

Genes

TRPV4
TRPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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