Article
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
Nature communications - 6 Feb 2017
Law Philip J, Berndt Sonja I, Speedy Helen E, Camp Nicola J, Sava Georgina P, Skibola Christine F, Holroyd Amy, Joseph Vijai, Sunter Nicola J, Nieters Alexandra, Bea Silvia, Monnereau Alain, Martin-Garcia David, Goldin Lynn R, Clot Guillem, Teras Lauren R, Quintela Inés, Birmann Brenda M, Jayne Sandrine, Cozen Wendy, Majid Aneela, Smedby Karin E, Lan Qing, Dearden Claire, Brooks-Wilson Angela R, Hall Andrew G, Purdue Mark P, Mainou-Fowler Tryfonia, Vajdic Claire M, Jackson Graham H, Cocco Pierluigi, Marr Helen, Zhang Yawei, Zheng Tongzhang, Giles Graham G, Lawrence Charles, Call Timothy G, Liebow Mark, Melbye Mads, Glimelius Bengt, Mansouri Larry, Glenn Martha, Curtin Karen, Diver W Ryan, Link Brian K, Conde Lucia, Bracci Paige M, Holly Elizabeth A, Jackson Rebecca D, Tinker Lesley F, Benavente Yolanda, Boffetta Paolo, Brennan Paul, Maynadie Marc, McKay James, Albanes Demetrius, Weinstein Stephanie, Wang Zhaoming, Caporaso Neil E, Morton Lindsay M, Severson Richard K, Riboli Elio, Vineis Paolo, Vermeulen Roel C H, Southey Melissa C, Milne Roger L, Clavel Jacqueline, Topka Sabine, Spinelli John J, Kraft Peter, Ennas Maria Grazia, Summerfield Geoffrey, Ferri Giovanni M, Harris Robert J, Miligi Lucia, Pettitt Andrew R, North Kari E, Allsup David J, Fraumeni Joseph F, Bailey James R, Offit Kenneth, Pratt Guy, Hjalgrim Henrik, Pepper Chris, Chanock Stephen J, Fegan Chris, Rosenquist Richard, de Sanjose Silvia, Carracedo Angel, Dyer Martin J S, Catovsky Daniel, Campo Elias, Cerhan James R, Allan James M, Rothman Nathanial, Houlston Richard, Slager Susan
Abstract excerpt
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10-13),...