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A cfDNA methylation-based tissue-of-origin classifier for cancers of unknown primary

17 Apr 2024

Abstract excerpt

Cancers of Unknown Primary (CUP) remains a diagnostic and therapeutic challenge due to biological heterogeneity and poor responses to standard chemotherapy. Predicting tissue-of-origin (TOO) molecularly could help refine this diagnosis, with tissue acquisition barriers mitigated via liquid biopsies. However, TOO liquid biopsies are unexplored in CUP cohorts. Here we describe CUPiD, a machine learning classifier...

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PMID: 38632274
DOI: 10.1038/s41467-024-47195-7

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