Article
The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation.
Cold Spring Harbor perspectives in medicine - 1 Sept 2016
Levine Arnold J, Puzio-Kuter Anna M, Chan Chang S, Hainaut Pierre
Abstract excerpt
The p53 protein plays a passive and an active role in stem cells. The transcriptional activities of p53 for cell-cycle arrest and DNA repair are largely turned off in stem cells, but there is some indication that long-term stem-cell viability may require other p53-regulated functions. When p53 is activated in stem cells, it stops cell division and promotes the commitment to a differentiation pathway and the...
Topics
- Cell Division
- DNA Replication
- Epigenesis, Genetic
- Humans
- Mutation
- Neoplasms
- Stem Cells
- Tumor Suppressor Protein p53