Article
Somatic stem cells and the origin of cancer.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Sept 2006
Martínez-Climent José A, Andreu Enrique J, Prosper Felipe
Abstract excerpt
Most human cancers derive from a single cell targeted by genetic and epigenetic alterations that initiate malignant transformation. Progressively, these early cancer cells give rise to different generations of daughter cells that accumulate additional mutations, acting in concert to drive the full neoplastic phenotype. As we have currently deciphered many of the gene pathways disrupted in cancer, our knowledge...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.