p53 and its mutants on the slippery road from stemness to carcinogenesis.

doi:10.1093/carcin/bgw092

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Article

p53 and its mutants on the slippery road from stemness to carcinogenesis.

Carcinogenesis - 1 Apr 2017

Molchadsky Alina, Rotter Varda

Abstract excerpt

Normal development, tissue homeostasis and regeneration following injury rely on the proper functions of wide repertoire of stem cells (SCs) persisting during embryonic period and throughout the adult life. Therefore, SCs employ robust mechanisms to preserve their genomic integrity and avoid heritage of mutations to their daughter cells. Importantly, propagation of SCs with faulty DNA as well as dedifferentiation...

Topics

Animals
Carcinogenesis
Humans
Mutation
Neoplasms
Neoplastic Stem Cells
Oncogenes
Phenotype
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 28334334
DOI: 10.1093/carcin/bgw092

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